The immune response to the intramuscular influenza vaccine initially develops in the spleen?

influenza
Maighdin asked:


True or false?

The antigen-binding site on an immunoglobulin binds epitopes only in the context of MHC class I or class II molecules. True or false?
Would the first one be false? Wouldn’t develop in the lymph node?
Second one is false?

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1 Comment so far

  1. cytotoxictlymphocyte on January 19th, 2010

    I would say both are false but the first one is a bit vague. All you Tcells and such arise from bone stem cells, but they mature and are generally activated in the thymus but are protective in the lymph/blood stream.

    As for the second question, immunoglobin is just an anti-body which binds epitopes anywhere it can find them.

    T-cell receptors, on the other hand, only lead to T-cell activation when they recognize an epitode bound to MHC.

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